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In 1911, Peyton Rous, being aware of similar previous experiments on the transmission of leukaemias between chicken by VilhelmEllerman and Olaf Bang [1], had shown that cell-free extracts from chicken sarcomas induced sarcomas in healthy chickens [2]. He concluded that a “minute parasitic organism” or a “chemical stimulant, elaborated by the neoplastic cells” must be responsible for sarcoma formation [2]. Later, the causative agent was identified to be a retrovirus and called the Rous sarcoma virus (RSV) [3]. However, it took 55 years and the discovery of the Epstein-Barr virus, the first human tumour virus [3,4], before Peyton Rouse eventually received the Nobel Prize for his work in 1966. © 2015 Cinatl J Jr., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Jindrich Cinatl Jr.1 and Martin Michaelis2* 2016-06-30T14:19:06+05:30 2016-06-30T14:19:06+05:30 2016-06-30T14:19:06+05:30 4 Adobe InDesign CS6 (Windows) uuid:673b2a4a-9ab1-41c7-9dc2-699912d8063a xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:668FF60A9F3EE61199449B81D5FAE482 proof:pdf xmp.iid:A5F2FBC8853EE611BDF29BF10BBE180A xmp.did:596E10D992C8E411A9F7BE0811E790A6 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2016-06-30T14:19:06+05:30 Citation: Cinatl J Jr., Michaelis M (2015) Cytomegalovirus and Cancer: A Long and Winding Road toConclusive Evidence. J Virol Emerg Dis 1 (2): doihttp://dx.doi.org/10.16966/jved.106 Martin Michaelis, 2Centre for Molecular Processing and School ofBiosciences, University of Kent, Canterbury CT2 7NJ, United Kingdom, E-mail: M.Michaelis@kent.ac.uk Adobe PDF Library 10.0.1 False endstream endobj 477 0 obj <> endobj xref 0 1268 0000000000 65535 f 0000206520 00000 n 0000206961 00000 n 0000207606 00000 n 0000216220 00000 n 0000216279 00000 n 0000216708 00000 n 0000217699 00000 n 0000217830 00000 n 0000225670 00000 n 0000225754 00000 n 0000225814 00000 n 0000225890 00000 n 0000226426 00000 n 0000226502 00000 n 0000226539 00000 n 0000263363 00000 n 0000263734 00000 n 0000264076 00000 n 0000264191 00000 n 0000264254 00000 n 0000264568 00000 n 0000265046 00000 n 0000265163 00000 n 0000265226 00000 n 0000265506 00000 n 0000265695 00000 n 0000265771 00000 n 0000265848 00000 n 0000265870 00000 n 0000265946 00000 n 0000266023 00000 n 0000266045 00000 n 0000266174 00000 n 0000266711 00000 n 0000266736 00000 n 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65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f trailer <<6907A5F84525E64BAF770BA96BA8EB03>]>> startxref 116 %%EOF 476 0 obj <>stream application/pdf Cytomegalovirus and Cancer: A Long andWinding Road to Conclusive Evidence It has long been known that collecting convincing evidence relating a certain virus to the formation of one or more cancer type(s) is a tedious task. In 1911, Peyton Rous, being aware of similar previous experiments on the transmission of leukaemias between chicken by VilhelmEllerman and Olaf Bang [1], had shown that cell-free extracts from chicken sarcomas induced sarcomas in healthy chickens [2]. He concluded that a “minute parasitic organism” or a “chemical stimulant, elaborated by the neoplastic cells” must be responsible for sarcoma formation [2]. Later, the causative agent was identified to be a retrovirus and called the Rous sarcoma virus (RSV) [3]. However, it took 55 years and the discovery of the Epstein-Barr virus, the first human tumour virus [3,4], before Peyton Rouse eventually received the Nobel Prize for his work in 1966. © 2015 Cinatl J Jr., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Jindrich Cinatl Jr.1 and Martin Michaelis2* 2016-06-30T14:19:06+05:30 2016-06-30T14:19:10+05:30 2016-06-30T14:19:10+05:30 4 Adobe InDesign CS6 (Windows) uuid:ac1782cf-ab48-45f6-b851-1ce3f8c457f8 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:668FF60A9F3EE61199449B81D5FAE482 proof:pdf xmp.iid:A5F2FBC8853EE611BDF29BF10BBE180A xmp.did:596E10D992C8E411A9F7BE0811E790A6 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2016-06-30T14:19:06+05:30 Citation: Cinatl J Jr., Michaelis M (2015) Cytomegalovirus and Cancer: A Long and Winding Road toConclusive Evidence. J Virol Emerg Dis 1 (2): doihttp://dx.doi.org/10.16966/jved.106 Martin Michaelis, 2Centre for Molecular Processing and School ofBiosciences, University of Kent, Canterbury CT2 7NJ, United Kingdom, E-mail: M.Michaelis@kent.ac.uk Adobe PDF Library 10.0.1 False endstream endobj 477 0 obj <> endobj 1269 0 obj <>/Metadata 476 0 R/Names 1270 0 R/Outlines 459 0 R/PageMode/UseOutlines/Pages 475 0 R/StructTreeRoot 478 0 R/Type/Catalog/ViewerPreferences<>>> endobj xref 0 1 0000000000 65535 f 476 2 0000409906 00000 n 0000416920 00000 n 1269 1 0000418115 00000 n trailer <<5FD4C7E1A11B8F44BAA97811EDF5C565>]/Prev 116>> startxref 418319 %%EOF