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EOn{W`;8Xc==r8t#yOG:ܐcI*adnbHf†N,[ [&b,ˉKr"&>H<|D&|<b] 9e${> d J}(9+9+9+97rnȹs#F^TB*!IY'NR:IuTur'Wqr|!;b#':rw9W x2Ȁn E *A@DE#a@Lt܃s&{yyŦPnBQ5 F(5P*BASgJCBT uBL!|CR,Q&J䑖G`*RPq#c8*%)x~C(ES?:cpviovBSq( vTUmcUƐ3¹J P8!Nuj,J&u@_ U]aEPXBaEDQ*خ` ~[؅MDS8jBI^ bZ,TH=P}2PւC (xxFRծT}ӧyyy]7e KKƋƋƋ[ƛ٦b fqƻk+kk&[ YŹh 9-N<(J d)5Z&&a@AGyQfgEyvQ> endobj 364 0 obj <> endobj 365 0 obj <>stream application/pdf Metformin Use in Type 2 Diabetes MellitusTuberculosis Co-infection and the Risk of LacticAcidosis: A Case Risk-Study © 2017 Novita BN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Metformin (MET) has possibilities to be utilized as an adjunct of TB therapy in controlling the growth of Mycobacterium tuberculosis (Mtb). MET enhances the production of mitochondrial reactive oxygen species and facilitates phagosome-lysosome fusion, those mechanism are important in Mtb elimination. Moreover, MET associated lactic acidosis (MALA) needs to be considered and the incidence of MALA in patients with type 2 DM-TB co-infection remains unknown. This result contributes much to our understanding about the clinical effect of MET use in type 2 DM-TB co-infection. Bernadette Dian Novita1 2* Endang Isbandiati Soediono1 Ni Made Mertaniasih3 Agung Pranoto4 and Wuryani5 Type 2 diabetes mellitus-tuberculosis co-infection Metformin Lactic acidosis 2017-03-17T10:29:15+05:30 2017-03-17T10:29:18+05:30 2017-03-17T10:29:18+05:30 4 Adobe InDesign CS6 (Windows) uuid:d0812300-47f4-4026-8fff-b00652010e13 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:4B297070CE0AE7118F81A80FB9F3228A proof:pdf converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2017-03-17T10:29:15+05:30 xmp.iid:4A297070CE0AE7118F81A80FB9F3228A xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default Bernadette Dian Novita, Division of Post Graduated Program ofPharmacology and Therapeutic, Department of Pharmacology, Faculty of Medicine, University ofAir langga, Surabaya Indonesia, Tel: +62-812-3547540; E-mail: diannovitakrisdianto@yahoo.co.id Citation: Novita BN, Soediono EI, Mertaniasih NM,Pranoto A, Wuryani (2017) Metformin Use in Type2 Diabetes Mellitus Tuberculosis Co-infection and theRisk of Lactic Acidosis: A Case Risk-Study. 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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Metformin (MET) has possibilities to be utilized as an adjunct of TB therapy in controlling the growth of Mycobacterium tuberculosis (Mtb). MET enhances the production of mitochondrial reactive oxygen species and facilitates phagosome-lysosome fusion, those mechanism are important in Mtb elimination. Moreover, MET associated lactic acidosis (MALA) needs to be considered and the incidence of MALA in patients with type 2 DM-TB co-infection remains unknown. This result contributes much to our understanding about the clinical effect of MET use in type 2 DM-TB co-infection. Bernadette Dian Novita1 2* Endang Isbandiati Soediono1 Ni Made Mertaniasih3 Agung Pranoto4 and Wuryani5 Type 2 diabetes mellitus-tuberculosis co-infection Metformin Lactic acidosis 2017-03-17T10:29:15+05:30 2017-03-17T10:29:39+05:30 2017-03-17T10:29:39+05:30 4 Adobe InDesign CS6 (Windows) uuid:93a6b28c-b451-4f3e-9e38-cf2de95de07a xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:4B297070CE0AE7118F81A80FB9F3228A proof:pdf converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2017-03-17T10:29:15+05:30 xmp.iid:4A297070CE0AE7118F81A80FB9F3228A xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default Bernadette Dian Novita, Division of Post Graduated Program ofPharmacology and Therapeutic, Department of Pharmacology, Faculty of Medicine, University ofAir langga, Surabaya Indonesia, Tel: +62-812-3547540; E-mail: diannovitakrisdianto@yahoo.co.id Citation: Novita BN, Soediono EI, Mertaniasih NM,Pranoto A, Wuryani (2017) Metformin Use in Type2 Diabetes Mellitus Tuberculosis Co-infection and theRisk of Lactic Acidosis: A Case Risk-Study. J Infect PulmDis 3(2): doi http://dx.doi.org/10.16966/2470-3176.124 Adobe PDF Library 10.0.1 False endstream endobj 366 0 obj <> endobj 1446 0 obj <>/Metadata 365 0 R/Names 1447 0 R/Outlines 313 0 R/PageMode/UseOutlines/Pages 364 0 R/StructTreeRoot 367 0 R/Type/Catalog/ViewerPreferences<>>> endobj xref 0 1 0000000000 65535 f 365 2 0000422730 00000 n 0000430088 00000 n 1446 1 0000431025 00000 n trailer <<960F6D42D0B42F418E8F074795AB75FF>]/Prev 116>> startxref 431229 %%EOF