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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Schizophrenia (SCZ) is a highly heritable, severe, common psychotic disorder. Genetic variants play an important role in SCZ pathogenesis and progression. Preclinical and clinical findings, particularly in the genome-wide association studies (GWAS), have identified transcriptional factor 4 (TCF4, E2-2) as a high risk gene for SCZ. Disruption of TCF4 expression and function has been also linked to Pitt-Hopkins syndrome (PTHS). TCF4 is well known to regulate neuronal lineage differentiation during embryonic and adult neurogenesis. Recent studies have identified a novel role of Tcf4 in regulating the neurite branching/pruning and synaptic plasticity of postmitotic differentiated neurons. Further understanding of the cellular and molecular mechanisms underlying the neurodevelopmental disorders and neuropsychological/neuropsychiatric diseases associated with TCF4 deficiency or dysfunction will provide important translational targets for the treatment of SCZ and PTHS. Schizophrenia TCF4 CRISPR-Cas9 Neurons Neurogenesis Ting Zhang1 Chaoran Yin1 Xiao Xiao1 Daniel R. Marenda2 and Wenhui Hu1* 2017-01-27T13:54:56+05:30 2017-01-27T13:54:57+05:30 2017-01-27T13:54:57+05:30 5 Adobe InDesign CS6 (Windows) uuid:9e9dc5b8-5bb2-4c68-add9-bf2a5f34a412 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:FE42CC066AE4E6118B1FE109C0962E78 proof:pdf converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2017-01-27T13:54:56+05:30 xmp.iid:FD42CC066AE4E6118B1FE109C0962E78 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default Wenhui Hu, Department of Neuroscience, Temple University Lewis KatzSchool of Medicine, USA, Tel: 215-707-5164; E-mail: whu@temple.edu Citation: Zhang T, Yin C, Hu W (2017)Transcriptional Factor 4 Association withSchizophrenia. 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65535 f 0000000000 65535 f trailer <]>> startxref 116 %%EOF 787 0 obj <>stream application/pdf Transcriptional Factor 4 Association withSchizophrenia © 2017 Zhang T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Schizophrenia (SCZ) is a highly heritable, severe, common psychotic disorder. Genetic variants play an important role in SCZ pathogenesis and progression. Preclinical and clinical findings, particularly in the genome-wide association studies (GWAS), have identified transcriptional factor 4 (TCF4, E2-2) as a high risk gene for SCZ. Disruption of TCF4 expression and function has been also linked to Pitt-Hopkins syndrome (PTHS). TCF4 is well known to regulate neuronal lineage differentiation during embryonic and adult neurogenesis. Recent studies have identified a novel role of Tcf4 in regulating the neurite branching/pruning and synaptic plasticity of postmitotic differentiated neurons. Further understanding of the cellular and molecular mechanisms underlying the neurodevelopmental disorders and neuropsychological/neuropsychiatric diseases associated with TCF4 deficiency or dysfunction will provide important translational targets for the treatment of SCZ and PTHS. Schizophrenia TCF4 CRISPR-Cas9 Neurons Neurogenesis Ting Zhang1 Chaoran Yin1 Xiao Xiao1 Daniel R. Marenda2 and Wenhui Hu1* 2017-01-27T13:54:56+05:30 2017-01-27T13:55:03+05:30 2017-01-27T13:55:03+05:30 5 Adobe InDesign CS6 (Windows) uuid:43f8f1c8-1413-4f94-86d1-02e0cd17f47c xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:FE42CC066AE4E6118B1FE109C0962E78 proof:pdf converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2017-01-27T13:54:56+05:30 xmp.iid:FD42CC066AE4E6118B1FE109C0962E78 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default Wenhui Hu, Department of Neuroscience, Temple University Lewis KatzSchool of Medicine, USA, Tel: 215-707-5164; E-mail: whu@temple.edu Citation: Zhang T, Yin C, Hu W (2017)Transcriptional Factor 4 Association withSchizophrenia. J Psychiatry Ment Health 2(1): doihttp://dx.doi.org/10.16966/2474-7769.115 Adobe PDF Library 10.0.1 False endstream endobj 788 0 obj <> endobj 2199 0 obj <>/Metadata 787 0 R/Names 2200 0 R/Outlines 745 0 R/PageMode/UseOutlines/Pages 786 0 R/StructTreeRoot 789 0 R/Type/Catalog/ViewerPreferences<>>> endobj xref 0 1 0000000000 65535 f 787 2 0000462851 00000 n 0000470321 00000 n 2199 1 0000471591 00000 n trailer <<00976508BE421C4394E3295B7949272A>]/Prev 116>> startxref 471795 %%EOF