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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Although body temperature is one of the most tightly regulated homeostatic parameters in humans, temperature abnormalities are frequently encountered in the in-hospital patient population, particularly in those with central nervous system (CNS) pathologies. CNS injuries are a prevalent cause of death and disability in young persons and on the rise among older persons. Brain and body temperature fluctuations in patients with cerebral pathologies are as of yet poorly characterized. The objective of this paper was to review our state of knowledge about spontaneous temperature fluctuations, specifically as they pertain to neurological patients. We provide an overview of the data on spontaneous temperature fluctuations (hyperthermia and hypothermia). ‘Is Hotter Better?’ evaluates how ambient temperature impacts human thermoregulation and health, reviews therapeutic benefits of induced hyperthermia, and discusses adverse outcomes of spontaneous hypothermia. In ‘Is Colder Cooler?,’ we review the link between fever and poor outcomes, the detrimental effects of spontaneous hypothermia on mortality, beneficial cerebral effects of spontaneous hypothermia after ischemic brain insult, and the clinical role of therapeutic hypothermia. We conclude that the net effects of early and spontaneous body temperature fluctuations in illness likely depend on the underlying pathological process, specific tissue vulnerabilities towards temperature-induced collateral damage, and the magnitude and duration of spontaneous temperature fluctuations. The paper calls for the community to expand our attention to investigating effects of the entire range of spontaneous body temperature fluctuations in CNS illness, because at present, the therapeutic effect of targeted temperature management in neurological patients remains uncertain. Bonnie Wang1 Martina L Mustroph2 and Huan Wang2* Spontaneous temperature fluctuations Hyperthermia Hypothermia Dysthermia Neurological patients 2016-07-11T19:03:55+05:30 2016-07-11T19:03:56+05:30 2016-07-11T19:03:56+05:30 5 Adobe InDesign CS6 (Windows) uuid:796ad1d2-0b81-4fdb-963f-874fd6d07082 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:1AB87C166C47E611900A87D9FE39DAE9 proof:pdf xmp.iid:19B87C166C47E611900A87D9FE39DAE9 xmp.did:24EDAEA39FC8E411BB3BED99DE70EEB1 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2016-07-11T19:03:55+05:30 Citation: Wang B, Mustroph ML, Wang H (2016)Spontaneous Body Temperature Fluctuations inNeurological Patients. J Neurol Neurobiol 2(4): doihttp://dx.doi.org/10.16966/2379-7150.127 Huan Wang, Carle Foundation Hospital, Beckman Institute of AdvancedScience and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA, Tel:2175523425; E-mail: John.wang@carle.com Adobe PDF Library 10.0.1 False endstream endobj 818 0 obj <> endobj xref 0 2452 0000000000 65535 f 0000206730 00000 n 0000207185 00000 n 0000207209 00000 n 0000217084 00000 n 0000217143 00000 n 0000217599 00000 n 0000217622 00000 n 0000217753 00000 n 0000226808 00000 n 0000226892 00000 n 0000226952 00000 n 0000227411 00000 n 0000227534 00000 n 0000227667 00000 n 0000236916 00000 n 0000237001 00000 n 0000237061 00000 n 0000237505 00000 n 0000238374 00000 n 0000238507 00000 n 0000247813 00000 n 0000262506 00000 n 0000262760 00000 n 0000263113 00000 n 0000263198 00000 n 0000263258 00000 n 0000263691 00000 n 0000264660 00000 n 0000264793 00000 n 0000273804 00000 n 0000273889 00000 n 0000273949 00000 n 0000274382 00000 n 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0000000000 65535 f 0000000000 65535 f 0000000000 65535 f trailer <<6B223BBEDA3EFA479AB576B882CCBE0A>]>> startxref 116 %%EOF 817 0 obj <>stream application/pdf Spontaneous Body Temperature Fluctuations inNeurological Patients © 2016 Wang B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Although body temperature is one of the most tightly regulated homeostatic parameters in humans, temperature abnormalities are frequently encountered in the in-hospital patient population, particularly in those with central nervous system (CNS) pathologies. CNS injuries are a prevalent cause of death and disability in young persons and on the rise among older persons. Brain and body temperature fluctuations in patients with cerebral pathologies are as of yet poorly characterized. The objective of this paper was to review our state of knowledge about spontaneous temperature fluctuations, specifically as they pertain to neurological patients. We provide an overview of the data on spontaneous temperature fluctuations (hyperthermia and hypothermia). ‘Is Hotter Better?’ evaluates how ambient temperature impacts human thermoregulation and health, reviews therapeutic benefits of induced hyperthermia, and discusses adverse outcomes of spontaneous hypothermia. In ‘Is Colder Cooler?,’ we review the link between fever and poor outcomes, the detrimental effects of spontaneous hypothermia on mortality, beneficial cerebral effects of spontaneous hypothermia after ischemic brain insult, and the clinical role of therapeutic hypothermia. We conclude that the net effects of early and spontaneous body temperature fluctuations in illness likely depend on the underlying pathological process, specific tissue vulnerabilities towards temperature-induced collateral damage, and the magnitude and duration of spontaneous temperature fluctuations. The paper calls for the community to expand our attention to investigating effects of the entire range of spontaneous body temperature fluctuations in CNS illness, because at present, the therapeutic effect of targeted temperature management in neurological patients remains uncertain. Bonnie Wang1 Martina L Mustroph2 and Huan Wang2* Spontaneous temperature fluctuations Hyperthermia Hypothermia Dysthermia Neurological patients 2016-07-11T19:03:55+05:30 2016-07-11T19:04+05:30 2016-07-11T19:04+05:30 5 Adobe InDesign CS6 (Windows) uuid:48a74c8e-4058-4b6e-b488-5669a22500bb xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:1AB87C166C47E611900A87D9FE39DAE9 proof:pdf xmp.iid:19B87C166C47E611900A87D9FE39DAE9 xmp.did:24EDAEA39FC8E411BB3BED99DE70EEB1 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2016-07-11T19:03:55+05:30 Citation: Wang B, Mustroph ML, Wang H (2016)Spontaneous Body Temperature Fluctuations inNeurological Patients. J Neurol Neurobiol 2(4): doihttp://dx.doi.org/10.16966/2379-7150.127 Huan Wang, Carle Foundation Hospital, Beckman Institute of AdvancedScience and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA, Tel:2175523425; E-mail: John.wang@carle.com Adobe PDF Library 10.0.1 False endstream endobj 818 0 obj <> endobj 2453 0 obj <>/Metadata 817 0 R/Names 2454 0 R/Outlines 775 0 R/PageMode/UseOutlines/Pages 816 0 R/StructTreeRoot 819 0 R/Type/Catalog/ViewerPreferences<>>> endobj xref 0 1 0000000000 65535 f 817 2 0000485166 00000 n 0000493563 00000 n 2453 1 0000495709 00000 n trailer <]/Prev 116>> startxref 495913 %%EOF