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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background: In this study the muscle bioenergetic function in response to exercise in severe ME was explored to see if the underlying metabolic problem in ME, responsible for the severe difficulties with trivial exercise, and the sever loss of muscle power, could be discovered. Methods: Inorganic phosphate, creatine kinase and lactate were measured in a former Dutch National Field Hockey Champion, who is now a patient bedridden with severe ME, before and 5 minutes after very trivial “exercise”, from which his muscles needed 12 hours to recover. Results: Inorganic phosphate and creatine kinase were both normal, however, lactate after this trivial exercise was very high, and further testing showed that a second batch of lactic acid was excreted after the same exercise with a 6-fold delay, showing that the lactic acid excretion was impaired and split into two. And this was delayed up to 11- fold by eating closer to the exercise. Mark Vink* Myalgic encephalomyelitis Chronic fatigue syndrome Exercise Muscle fatigue Muscle pain Lactate Lactic acid Immunedysfunction Inorganic phosphate Creatine kinase 2015-09-17T12:06:13+05:30 2015-09-17T12:06:15+05:30 2015-09-17T12:06:15+05:30 5 Adobe InDesign CS6 (Windows) uuid:7d9b00b1-ab25-4f04-8cf3-f89323313fc1 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:2796795E065DE511A5D2AE08878EB7BE proof:pdf xmp.iid:2696795E065DE511A5D2AE08878EB7BE xmp.did:24EDAEA39FC8E411BB3BED99DE70EEB1 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2015-09-17T12:06:13+05:30 Vink M (2015) The Aerobic EnergyProduction and the Lactic Acid Excretion are bothImpeded in Myalgic Encephalomyelitis/ChronicFatigue Syndrome. J Neurol Neurobiol 1(4): doi http://dx.doi.org/10.16966/2379-7150.112 Mark Vink, MD, Family Physician/GPwSI, Soerabaja Research CenterAmstel 38, 1096 HH Amsterdam, The Netherlands, E-mail: markvink.md@outlook.com Adobe PDF Library 10.0.1 False endstream endobj 591 0 obj <> endobj xref 0 2268 0000000000 65535 f 0000240826 00000 n 0000241253 00000 n 0000241277 00000 n 0000250604 00000 n 0000250663 00000 n 0000251105 00000 n 0000251128 00000 n 0000251262 00000 n 0000260090 00000 n 0000260174 00000 n 0000260234 00000 n 0000260718 00000 n 0000260743 00000 n 0000260879 00000 n 0000269941 00000 n 0000270055 00000 n 0000270140 00000 n 0000270200 00000 n 0000270646 00000 n 0000270671 00000 n 0000270807 00000 n 0000279752 00000 n 0000279837 00000 n 0000279897 00000 n 0000280329 00000 n 0000280354 00000 n 0000280490 00000 n 0000289770 00000 n 0000289855 00000 n 0000289915 00000 n 0000290361 00000 n 0000290463 00000 n 0000290599 00000 n 0000299556 00000 n 0000299641 00000 n 0000299701 00000 n 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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background: In this study the muscle bioenergetic function in response to exercise in severe ME was explored to see if the underlying metabolic problem in ME, responsible for the severe difficulties with trivial exercise, and the sever loss of muscle power, could be discovered. Methods: Inorganic phosphate, creatine kinase and lactate were measured in a former Dutch National Field Hockey Champion, who is now a patient bedridden with severe ME, before and 5 minutes after very trivial “exercise”, from which his muscles needed 12 hours to recover. Results: Inorganic phosphate and creatine kinase were both normal, however, lactate after this trivial exercise was very high, and further testing showed that a second batch of lactic acid was excreted after the same exercise with a 6-fold delay, showing that the lactic acid excretion was impaired and split into two. And this was delayed up to 11- fold by eating closer to the exercise. Mark Vink* Myalgic encephalomyelitis Chronic fatigue syndrome Exercise Muscle fatigue Muscle pain Lactate Lactic acid Immunedysfunction Inorganic phosphate Creatine kinase 2015-09-17T12:06:13+05:30 2015-09-17T12:06:22+05:30 2015-09-17T12:06:22+05:30 5 Adobe InDesign CS6 (Windows) uuid:3ec788d5-998b-4a62-8722-aff71ab253b9 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:2796795E065DE511A5D2AE08878EB7BE proof:pdf xmp.iid:2696795E065DE511A5D2AE08878EB7BE xmp.did:24EDAEA39FC8E411BB3BED99DE70EEB1 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2015-09-17T12:06:13+05:30 Vink M (2015) The Aerobic EnergyProduction and the Lactic Acid Excretion are bothImpeded in Myalgic Encephalomyelitis/ChronicFatigue Syndrome. J Neurol Neurobiol 1(4): doi http://dx.doi.org/10.16966/2379-7150.112 Mark Vink, MD, Family Physician/GPwSI, Soerabaja Research CenterAmstel 38, 1096 HH Amsterdam, The Netherlands, E-mail: markvink.md@outlook.com Adobe PDF Library 10.0.1 False endstream endobj 591 0 obj <> endobj 2269 0 obj <>/Metadata 590 0 R/Names 2270 0 R/Outlines 534 0 R/PageMode/UseOutlines/Pages 589 0 R/StructTreeRoot 592 0 R/Type/Catalog/ViewerPreferences<>>> endobj xref 0 1 0000000000 65535 f 590 2 0000518331 00000 n 0000526005 00000 n 2269 1 0000527304 00000 n trailer <<764283B53B665944A5BF39388779120A>]/Prev 116>> startxref 527508 %%EOF