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4fIaFI_$H)PN.dLIŔDLIÔN)QzV%TRJ%TRJdf\eTeLdDdy}r^ly[Jx (G@9JɑV]k .IPr#刜OD8 ʑPqDYt0ngh"!:2Xӡ䰂jzP6D9r? *D@ endstream endobj 688 0 obj <> endobj 689 0 obj <> endobj 690 0 obj <>stream application/pdf Role of Epigenetics in Cardiac Developmentand Cardiovascular Diseases Epigenetic mechanisms which comprise DNA methylation, histone modification, oxidative modification, and non-coding RNAs, are closely linked to cardiac development and dysfunction. However, the exact mechanisms remain unclear. More and more studies have represented altered DNA methylation or distinct changes in chromatin modifications within cardiovascular diseases including atherosclerosis, heart failure, myocardial infarction, and cardiac hypertrophy. © 2016 Wang K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Kun Wang Jianxun Wang and Peifeng Li* Cardiovascular diseases Cardiac biology DNA Methylation Histone modification Oxidative modification microRNAs 2018-02-05T18:37:43+05:30 2018-02-05T18:37:44+05:30 2018-02-05T18:37:44+05:30 5 Adobe InDesign CS6 (Windows) uuid:e0daff1a-e1ae-4720-8378-47c77f3bdace xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:E1171B7A750AE811A23FF003E2A94B20 proof:pdf xmp.iid:0D2D084A750AE811A23FF003E2A94B20 xmp.did:9A7BCE2A86C8E411A9F7BE0811E790A6 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2018-02-05T18:37:43+05:30 Citation: Dong Y, Sun T, Wang K, Wang J, Li P (2016) Role of Epigenetics in Cardiac Development and Cardiovascular Diseases. J Hear Health 2(4): doi http://dx.doi.org/10.16966/2379-769X.131 Peifeng Li, Institute for Translational Medicine, Qingdao University, Deng Zhou Road 38, Qingdao 266021, China, Tel: 86-532-82991791; E-mail: peifli@qdu.edu.cn Adobe PDF Library 10.0.1 False endstream endobj 691 0 obj <> endobj xref 0 1918 0000000000 65535 f 0000209198 00000 n 0000209653 00000 n 0000209677 00000 n 0000219475 00000 n 0000219534 00000 n 0000220004 00000 n 0000220451 00000 n 0000220584 00000 n 0000229244 00000 n 0000229328 00000 n 0000229388 00000 n 0000229820 00000 n 0000230797 00000 n 0000230932 00000 n 0000239110 00000 n 0000239195 00000 n 0000239255 00000 n 0000239688 00000 n 0000240649 00000 n 0000240784 00000 n 0000249082 00000 n 0000249167 00000 n 0000249227 00000 n 0000249312 00000 n 0000249925 00000 n 0000250288 00000 n 0000250625 00000 n 0000251899 00000 n 0000267528 00000 n 0000267604 00000 n 0000268136 00000 n 0000268322 00000 n 0000268440 00000 n 0000268542 00000 n 0000268648 00000 n 0000268714 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which comprise DNA methylation, histone modification, oxidative modification, and non-coding RNAs, are closely linked to cardiac development and dysfunction. However, the exact mechanisms remain unclear. More and more studies have represented altered DNA methylation or distinct changes in chromatin modifications within cardiovascular diseases including atherosclerosis, heart failure, myocardial infarction, and cardiac hypertrophy. © 2016 Wang K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Kun Wang Jianxun Wang and Peifeng Li* Cardiovascular diseases Cardiac biology DNA Methylation Histone modification Oxidative modification microRNAs 2018-02-05T18:37:43+05:30 2018-02-05T18:37:49+05:30 2018-02-05T18:37:49+05:30 5 Adobe InDesign CS6 (Windows) uuid:c66167b1-80d3-4801-b7a4-d86b93eeb28a xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:E1171B7A750AE811A23FF003E2A94B20 proof:pdf xmp.iid:0D2D084A750AE811A23FF003E2A94B20 xmp.did:9A7BCE2A86C8E411A9F7BE0811E790A6 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2018-02-05T18:37:43+05:30 Citation: Dong Y, Sun T, Wang K, Wang J, Li P (2016) Role of Epigenetics in Cardiac Development and Cardiovascular Diseases. J Hear Health 2(4): doi http://dx.doi.org/10.16966/2379-769X.131 Peifeng Li, Institute for Translational Medicine, Qingdao University, Deng Zhou Road 38, Qingdao 266021, China, Tel: 86-532-82991791; E-mail: peifli@qdu.edu.cn Adobe PDF Library 10.0.1 False endstream endobj 691 0 obj <> endobj 1919 0 obj <>/Metadata 690 0 R/Names 1920 0 R/Outlines 652 0 R/PageMode/UseOutlines/Pages 689 0 R/StructTreeRoot 692 0 R/Type/Catalog/ViewerPreferences<>>> endobj xref 0 1 0000000000 65535 f 690 2 0000454451 00000 n 0000461444 00000 n 1919 1 0000462191 00000 n trailer <<3C95C14EF0C9574A894C3700B7575194>]/Prev 116>> startxref 462395 %%EOF