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Methods Enzyme-linked immunoabsorbent assay (ELISA) was performed in the presence or absence of different enzymatic and specific receptors’ antagonist drugs. The levels and the generation of PGE2, 6-keto-PGF1α and cyclic AMP (cAMP) in rat submandibular gland acini’s preparations and in serum from pSS patients were measured in the presence of pSS IgG anti M3 peptide. COX-2 mRNA gene’s expression at Real Time PCR was done in acini’s preparations from rat submandibular gland in the presence of the autoantibodies alone or once previously incubated with different inhibitors. Results In this study, we show that the activation of M3 mAChR of rat submandibular gland acini’s preparation triggers an increment both in the production of COX-2 mRNA gene’s expression and in the production of PGE2 and 6-keto-PGF1α. These phenomena are accompanied by an increment in the production of cAMP in the acini’s preparation and do not affect COX-1 mRNA’s levels. Both prostanoids are augmented in the sera of pSS patients as compared with healthy individuals. © 2015 Reina S et al This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Silvia Reina1 2 Cecilia Pisoni3 Alicia Eimon3 Carolina Carrizo3 SabrinaGanzinelli1 2 Roberto Arana3 and Enri Borda Autoantibodies Sjögren’ syndrome PGE2 PGI2 cAMP COX-2 mRNA 2015-08-13T15:14:38+05:30 2015-08-13T15:14:40+05:30 2015-08-13T15:14:40+05:30 5 Adobe InDesign CS6 (Windows) uuid:254601a7-13cd-413f-901c-ce6cec8e01ba xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:920385DD9F41E511985EB1C590F3387A proof:pdf xmp.iid:910385DD9F41E511985EB1C590F3387A xmp.did:F2BC7D9EC6C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2015-08-13T15:14:38+05:30 Reina S, Pisoni C, Eimon A, Carrizo C,Ganzinelli S, et al. (2015) Changes in Cyclooxygenase-2’s Expression, and PGE2’s and 6-keto-PGF1α’sLevels in the Presence of the MuscarinicAcethylcholine Receptor Antibody in Primary SjögrenSyndrome. Int J Dent Oral Health 1 (3): doi http://dx.doi.org/10.16966/2378-7090.115 Enri Borda, M.D., Ph.D., Pharmacology Unit, School of Dentistry, Universityof Buenos Aires,Marcelo T de Alvear 2142 – 4 “B”, 1122 AAH. 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65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f trailer <]>> startxref 116 %%EOF 430 0 obj <>stream application/pdf Changes in Cyclooxygenase-2’sExpression, and PGE2’s and 6-keto-PGF1α’sLevels in the Presence of the MuscarinicAcethylcholine Receptor Antibody inPrimary Sjögren Syndrome Abstract Aims This paper investigates the action of M3 muscarinic acetylcholine receptor antibody present in serum from patients with Sjögren syndrome (SS). Methods Enzyme-linked immunoabsorbent assay (ELISA) was performed in the presence or absence of different enzymatic and specific receptors’ antagonist drugs. The levels and the generation of PGE2, 6-keto-PGF1α and cyclic AMP (cAMP) in rat submandibular gland acini’s preparations and in serum from pSS patients were measured in the presence of pSS IgG anti M3 peptide. COX-2 mRNA gene’s expression at Real Time PCR was done in acini’s preparations from rat submandibular gland in the presence of the autoantibodies alone or once previously incubated with different inhibitors. Results In this study, we show that the activation of M3 mAChR of rat submandibular gland acini’s preparation triggers an increment both in the production of COX-2 mRNA gene’s expression and in the production of PGE2 and 6-keto-PGF1α. These phenomena are accompanied by an increment in the production of cAMP in the acini’s preparation and do not affect COX-1 mRNA’s levels. Both prostanoids are augmented in the sera of pSS patients as compared with healthy individuals. © 2015 Reina S et al This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Silvia Reina1 2 Cecilia Pisoni3 Alicia Eimon3 Carolina Carrizo3 SabrinaGanzinelli1 2 Roberto Arana3 and Enri Borda Autoantibodies Sjögren’ syndrome PGE2 PGI2 cAMP COX-2 mRNA 2015-08-13T15:14:38+05:30 2015-08-13T15:14:48+05:30 2015-08-13T15:14:48+05:30 5 Adobe InDesign CS6 (Windows) uuid:7b7f6caa-3038-4181-9365-f36a4cdc9b3d xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:920385DD9F41E511985EB1C590F3387A proof:pdf xmp.iid:910385DD9F41E511985EB1C590F3387A xmp.did:F2BC7D9EC6C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2015-08-13T15:14:38+05:30 Reina S, Pisoni C, Eimon A, Carrizo C,Ganzinelli S, et al. (2015) Changes in Cyclooxygenase-2’s Expression, and PGE2’s and 6-keto-PGF1α’sLevels in the Presence of the MuscarinicAcethylcholine Receptor Antibody in Primary SjögrenSyndrome. Int J Dent Oral Health 1 (3): doi http://dx.doi.org/10.16966/2378-7090.115 Enri Borda, M.D., Ph.D., Pharmacology Unit, School of Dentistry, Universityof Buenos Aires,Marcelo T de Alvear 2142 – 4 “B”, 1122 AAH. Ciudad Autónoma de Buenos Aires,Argentina, Tel: +54-11-4964-1276; E-mail: enri@farmaco.odon.uba.ar Adobe PDF Library 10.0.1 False endstream endobj 431 0 obj <> endobj 2113 0 obj <>/Metadata 430 0 R/Names 2114 0 R/Outlines 346 0 R/PageMode/UseOutlines/Pages 429 0 R/StructTreeRoot 432 0 R/Type/Catalog/ViewerPreferences<>>> endobj xref 0 1 0000000000 65535 f 430 2 0000860285 00000 n 0000868637 00000 n 2113 1 0000871650 00000 n trailer <]/Prev 116>> startxref 871854 %%EOF