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Of these, herbal agents and probiotics have emerged as popular therapeutic agents. The present study was attempted to comparatively evaluate for the first time the effects of both these agents on chronic periodontitis. Materials and methods In this double blinded randomized controlled clinical trial, 96 systemically healthy patients with chronic periodontitis between the ages of 25-55 years were randomly divided into 3 groups. Following scaling and root planning, group 1 was administered the herbal immunomodulator tablets twice daily for 2 weeks, group 2, probiotic tablets twice daily for 2 weeks and group 3 was not administered any agent. Changes in gingival index, gingival bleeding index, pocket depth and interleukin – 6 (IL-6) levels in saliva and GCF were assessed at day 0, at 1 month, at 3 months and 6 months following which statistical analysis was done. Results Statistically significant reduction (p<0.001) in clinical parameters and GCF IL-6 levels at 1, 3 and 6 months respectively within all 3 groups was observed. However, there was a significant reduction in salivary IL-6 levels within group 3 only. Group 1 showed better clinical results and salivary IL-6 reduction compared to group 2 and 3. Conclusion Both herbal and probiotic immunomodulators were effective when used as adjuncts to scaling and root planning in chronic periodontitis patients. Periodontitis Herbal immunomodulation Probiotics Interleukin – 6 ELISA © 2015 ©2015 Shetty S et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited 2015-12-05T17:57:53+05:30 2015-12-05T17:57:55+05:30 2015-12-05T17:57:55+05:30 5 Adobe InDesign CS6 (Windows) uuid:375802ba-df71-45c4-a051-9968ed615d14 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:0F676FA54A9BE511A4B0CD73E1057C1B proof:pdf xmp.iid:0E676FA54A9BE511A4B0CD73E1057C1B xmp.did:F2BC7D9EC6C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2015-12-05T17:57:53+05:30 Shetty S, Bose A, Thoudam B (2015) A Comparative Evaluation of Clinical Efficacy and Salivary and Gingival Crevicular Fluid Interleukin – 6 Levels with Herbal and Probiotic Host Modulation Therapy in Chronic Periodontal Disease. Int J Dent Oral health 1 (2): doi http://dx.doi.org/10.16966/ijdoh.111 Dr. Shreya Shetty, Department of Periodontics Bangalore Institute of Dental Sciences & Postgraduate Research, Hosur Road, Bangalore – 560029, India, Fax: +918041506025; E-mail: drshreyak@rediffmail.com Adobe PDF Library 10.0.1 False endstream endobj 366 0 obj <> endobj xref 0 4160 0000000000 65535 f 0000253720 00000 n 0000254200 00000 n 0000254231 00000 n 0000262145 00000 n 0000263427 00000 n 0000263714 00000 n 0000264048 00000 n 0000269036 00000 n 0000269409 00000 n 0000269876 00000 n 0000269936 00000 n 0000270420 00000 n 0000270452 00000 n 0000270588 00000 n 0000270722 00000 n 0000282273 00000 n 0000282358 00000 n 0000282443 00000 n 0000282503 00000 n 0000283002 00000 n 0000283034 00000 n 0000283170 00000 n 0000283304 00000 n 0000293826 00000 n 0000293911 00000 n 0000293996 00000 n 0000294056 00000 n 0000294528 00000 n 0000294560 00000 n 0000294696 00000 n 0000294830 00000 n 0000304817 00000 n 0000304902 00000 n 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0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f trailer <]>> startxref 116 %%EOF 365 0 obj <>stream application/pdf A Comparative Evaluation of Clinical Efficacy and Salivary and Gingival Crevicular Fluid Interleukin – 6 Levels with Herbal and Probiotic Host Modulation Therapy in Chronic Periodontal Disease Shreya Shetty* Aditi Bose and Bebika Thoudam Background Host modulation is fast gaining popularity as one of the most safe and effective therapeutic modalities in a number of systemic ailments and also periodontal disease. Of these, herbal agents and probiotics have emerged as popular therapeutic agents. The present study was attempted to comparatively evaluate for the first time the effects of both these agents on chronic periodontitis. Materials and methods In this double blinded randomized controlled clinical trial, 96 systemically healthy patients with chronic periodontitis between the ages of 25-55 years were randomly divided into 3 groups. Following scaling and root planning, group 1 was administered the herbal immunomodulator tablets twice daily for 2 weeks, group 2, probiotic tablets twice daily for 2 weeks and group 3 was not administered any agent. Changes in gingival index, gingival bleeding index, pocket depth and interleukin – 6 (IL-6) levels in saliva and GCF were assessed at day 0, at 1 month, at 3 months and 6 months following which statistical analysis was done. Results Statistically significant reduction (p<0.001) in clinical parameters and GCF IL-6 levels at 1, 3 and 6 months respectively within all 3 groups was observed. However, there was a significant reduction in salivary IL-6 levels within group 3 only. Group 1 showed better clinical results and salivary IL-6 reduction compared to group 2 and 3. Conclusion Both herbal and probiotic immunomodulators were effective when used as adjuncts to scaling and root planning in chronic periodontitis patients. Periodontitis Herbal immunomodulation Probiotics Interleukin – 6 ELISA © 2015 ©2015 Shetty S et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited 2015-12-05T17:57:53+05:30 2015-12-05T17:58:06+05:30 2015-12-05T17:58:06+05:30 5 Adobe InDesign CS6 (Windows) uuid:63b902fa-6abe-4ce9-ae74-7c2d0fa6bbd6 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:0F676FA54A9BE511A4B0CD73E1057C1B proof:pdf xmp.iid:0E676FA54A9BE511A4B0CD73E1057C1B xmp.did:F2BC7D9EC6C7E411AEB789ACBE3823B3 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2015-12-05T17:57:53+05:30 Shetty S, Bose A, Thoudam B (2015) A Comparative Evaluation of Clinical Efficacy and Salivary and Gingival Crevicular Fluid Interleukin – 6 Levels with Herbal and Probiotic Host Modulation Therapy in Chronic Periodontal Disease. Int J Dent Oral health 1 (2): doi http://dx.doi.org/10.16966/ijdoh.111 Dr. Shreya Shetty, Department of Periodontics Bangalore Institute of Dental Sciences & Postgraduate Research, Hosur Road, Bangalore – 560029, India, Fax: +918041506025; E-mail: drshreyak@rediffmail.com Adobe PDF Library 10.0.1 False endstream endobj 366 0 obj <> endobj 4161 0 obj <>/Metadata 365 0 R/Names 4162 0 R/Outlines 276 0 R/PageMode/UseOutlines/Pages 364 0 R/StructTreeRoot 367 0 R/Type/Catalog/ViewerPreferences<>>> endobj xref 0 1 0000000000 65535 f 365 2 0000557525 00000 n 0000565896 00000 n 4161 1 0000567896 00000 n trailer <]/Prev 116>> startxref 568100 %%EOF