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Lacking hormone receptors, ER and PR, as well as HER2 amplification, these cancers cannot be treated with more modern, targeted therapies such as tamoxifen or trastuzumab. Thus, the current standard of care for these patients is cytotoxic chemotherapy with varied clinical response. However, all patients experience unwanted and debilitating side effects regardless of response. Therefore, TNBC represents a significant unmet clinical need and finding more targeted and effective treatment approaches for this aggressive disease is an area of active research. The success of such agents has been hindered by the heterogeneity of the disease, with many new drugs only showing promising results in small populations. In order for targeted treatments to succeed, predictive biomarkers must be developed which can stratify patients and drive treatment choices. This review looks at the most promising areas of research regarding targeted therapy in TNBC as well as associated biomarkers that can be used to guide treatment. © 2018 Elkashif A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Ahmed Elkashif Helen O McCarthy and Niamh E Buckley* Triple negative breast cancer Biomarkers Personalised medicine Targeted treatment 2018-07-11T17:51:42+05:30 2018-07-11T17:51:44+05:30 2018-07-11T17:51:44+05:30 4 Adobe InDesign CS6 (Windows) uuid:f6fc377a-890d-41cc-8c8a-3bde18bf165b xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:E38CECF40485E811AA108B360DEC823E proof:pdf xmp.iid:E28CECF40485E811AA108B360DEC823E xmp.did:25700E8721B3E7119FB78DFA0FAB8027 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2018-07-11T17:51:42+05:30 Elkashif A, McCarthy HO, Buckley NE (2018) Personalising the Fight against Triple Negative Breast Cancer. J Breast Cancer Res Adv1(1): dx.doi.org/10.16966/jbcra.106 Niamh E Buckley, School of Pharmacy, Queen’s University Belfast, Northern Ireland, UK, Tel: 44 (0) 28 9097 5806;E-mail: n.obrien@qub.ac.uk http://dx.doi.org/10.16966/jbcra.106 Adobe PDF Library 10.0.1 False endstream endobj 1137 0 obj <> endobj xref 0 3504 0000000000 65535 f 0000273245 00000 n 0000273701 00000 n 0000282878 00000 n 0000282937 00000 n 0000283470 00000 n 0000292839 00000 n 0000292952 00000 n 0000293011 00000 n 0000293468 00000 n 0000302767 00000 n 0000302827 00000 n 0000303286 00000 n 0000312238 00000 n 0000312298 00000 n 0000312758 00000 n 0000321848 00000 n 0000321908 00000 n 0000322422 00000 n 0000322531 00000 n 0000331858 00000 n 0000331918 00000 n 0000332391 00000 n 0000333289 00000 n 0000344194 00000 n 0000344254 00000 n 0000344703 00000 n 0000345641 00000 n 0000357201 00000 n 0000357261 00000 n 0000357723 00000 n 0000358669 00000 n 0000370357 00000 n 0000370417 00000 n 0000370891 00000 n 0000371834 00000 n 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0000000000 65535 f 0000000000 65535 f 0000000000 65535 f trailer <<7320037C0372984EA3A20E9B5A51A2E9>]>> startxref 116 %%EOF 1136 0 obj <>stream application/pdf Personalising the Fight against Triple Negative Breast Cancer Triple Negative Breast Cancer (TNBC) is a highly heterogeneous disease. Lacking hormone receptors, ER and PR, as well as HER2 amplification, these cancers cannot be treated with more modern, targeted therapies such as tamoxifen or trastuzumab. Thus, the current standard of care for these patients is cytotoxic chemotherapy with varied clinical response. However, all patients experience unwanted and debilitating side effects regardless of response. Therefore, TNBC represents a significant unmet clinical need and finding more targeted and effective treatment approaches for this aggressive disease is an area of active research. The success of such agents has been hindered by the heterogeneity of the disease, with many new drugs only showing promising results in small populations. In order for targeted treatments to succeed, predictive biomarkers must be developed which can stratify patients and drive treatment choices. This review looks at the most promising areas of research regarding targeted therapy in TNBC as well as associated biomarkers that can be used to guide treatment. © 2018 Elkashif A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Ahmed Elkashif Helen O McCarthy and Niamh E Buckley* Triple negative breast cancer Biomarkers Personalised medicine Targeted treatment 2018-07-11T17:51:42+05:30 2018-07-11T17:51:48+05:30 2018-07-11T17:51:48+05:30 4 Adobe InDesign CS6 (Windows) uuid:84246f1f-f402-417a-99fe-2683ecdaa1b5 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 xmp.id:E38CECF40485E811AA108B360DEC823E proof:pdf xmp.iid:E28CECF40485E811AA108B360DEC823E xmp.did:25700E8721B3E7119FB78DFA0FAB8027 xmp.did:FE00469DB0C7E411AEB789ACBE3823B3 default converted from application/x-indesign to application/pdf Adobe InDesign CS6 (Windows) / 2018-07-11T17:51:42+05:30 Elkashif A, McCarthy HO, Buckley NE (2018) Personalising the Fight against Triple Negative Breast Cancer. J Breast Cancer Res Adv1(1): dx.doi.org/10.16966/jbcra.106 Niamh E Buckley, School of Pharmacy, Queen’s University Belfast, Northern Ireland, UK, Tel: 44 (0) 28 9097 5806;E-mail: n.obrien@qub.ac.uk http://dx.doi.org/10.16966/jbcra.106 Adobe PDF Library 10.0.1 False endstream endobj 1137 0 obj <> endobj 3505 0 obj <>/Metadata 1136 0 R/Names 3506 0 R/Outlines 1069 0 R/PageMode/UseOutlines/Pages 1133 0 R/StructTreeRoot 1138 0 R/Type/Catalog/ViewerPreferences<>>> endobj xref 0 1 0000000000 65535 f 1136 2 0000687350 00000 n 0000695015 00000 n 3505 1 0000696408 00000 n trailer <<76B597E4340C7449BEC0C32C67F6524E>]/Prev 116>> startxref 696616 %%EOF