传记

主要从事信号转导途径、分子生物学、分子免疫学及转译临床研究。在中国担任耳鼻喉科临床研究员期间，曾研究自身免疫性内耳疾病小鼠模型黏附分子表达。这段经历强烈激发了我对科学研究的兴趣。在博士期间，我研究了PI3K-Akt通路调控RNA聚合酶I和III基因转录的机制。通过研究，我们发现了一种新的RNA聚合酶I和III基因转录调控机制。此外，我还研究了肿瘤抑制基因PTEN在RNA聚合酶I和III基因转录调控中的作用。我们发现PTEN通过抑制RNA聚合酶I和III基因转录，抑制肿瘤的发生。在完成博士学业后，我还进行了博士后培训，然后进入了医学住院医师项目。在博士后期间，我研究了NF-γB信号通路在酒精性慢性胰腺炎发展中的作用。住院医师期间，我还完成了PI3K-Akt通路调控小肠上皮细胞Na+/ H+交换器3的机制研究课题。 During my gastroenterology fellowship, I also conducted research to identify the molecular mechanism by which Saccharomyces boulardii represses the EGFR activation in the small intestinal epithelial cells. While I have demonstrated a strong foundation of knowledge and rich experience of research in the field of molecular biology in the past, I also have experience of translation research in order to build the “bridge” from “bench” to “bedside”. During my gastroenterology fellowship training, I did research on mesalamine in celiac disease patients. In this research project, I studied the changes of cytokines profile in the small intestinal biopsy specimens from refractory celiac disease patients upon the treatment of mesalamine. After I joined the staff in the Division of Gastroenterology, Hepatology, & Nutrition at the Ohio State University Wexner Medical Center, I have lead multiple clinical research projects, including the study to investigate prevalence and outcomes of human cytomegalovirus disease in inflammatory bowel disease patients and national population study to investigate impact of timing of endoscopy on healthcare outcomes of patients with inflammatory bowel disease.

目前还参与多项研究项目，包括血清Ig a水平与炎症性肠病严重程度的相关性研究以及肠上皮细胞Ig a转运体在炎症性肠病进展中的作用研究。静脉注射羧麦芽糖铁治疗缺铁性贫血继发性炎症性肠病的疗效及对炎症性肠病患者血清细胞因子谱的影响同时，我还参与了一项多中心3期临床试验，研究Vedolizumab治疗原发性硬化性胆管炎合并炎症性肠病。我也是一项研究利福昔明诱导中度活动期克罗恩病临床缓解的有效性和安全性的主要研究者。